Upon successful completion of the course, the student will have achieved the following learning outcomes:
has advanced knowledge of topics, algorithms, tools and methods in the field of Bioinformatics
has knowledge of statistical methods for analysis of biological data
can analyze and use bioinformatic methods associated with advanced sequence alignment, database searches, genome analysis and protein structural studies
can use statistical operations in biology
can operate commonly used bioinformatics tools and understand their pros and cons
can statistically analyse data in a biologically relevant manner
Bioinformatics is a branch of science that uses computers for storage, retrieval, analysis, visualization and distribution of information related to biological macromolecules like DNA, RNA and proteins. It is an interdisciplinary field that includes biology, computer science, chemistry and statistics.
This course introduces key concepts and methods in bioinformatics. Major research topics in bioinformatics include sequence analysis structure analysis and functional analysis of biological data.
The course comprises two main parts:
A lecture-based part, introducing various web-based resources and bioinformatics tools for the analyses of DNA, RNA and protein sequences and lectures in elementary statistics.
Computer lab, where students will be guided through practical bioinformatics and biostatistics exercises on the computer.
Topics covered include
– Introduction to biological databases and database searching
– Pairwise and multiple sequence alignment
– Phylogenetic analysis
– Protein structure modelling
– Gene prediction
– Basics of genome sequencing and genome assembly
– Introduction to elemental statistical treatment of biological data
Teaching and working methods
Lectures: Introductory lectures are given to provide an overview of the main topics in the course.
Computer Lab: Practical exercises throughout the whole semester where the students will conduct a series of adapted computer tools to solve bioinformatics tasks
Compulsory Assignment: Students in groups of 3-4 are to hand in a written report of an assigned bioinformatic problem
Fronter: All relevant course information and scientific articles in the syllabus will be posted on Fronter.
Attendance to at least 80% of the Computer Lab exercises
written individual report count 40% of the final grade
individual 4-hour written exam count 60% of the final grade
Both exams must be passed to receive a final grade.
The exam will be evaluated by letter grade, A-F, where E is the lowest passing grade